This milkweed species has a unique flower with long, slender hoods that extend beyond the stigmatic groove and flare out or bow at the top. Despite having shallow roots, it can survive periodic droughts and occasional mowing. If there is a dry period, it will leaf out and flower when it rains. Populations of this plant tend to have a low density and are scattered, making it one of the least conspicuous milkweeds.

It thrives in full sun and tolerates sandy, dry soils, making it an excellent choice for butterfly gardens. In full sun, the upper leaves develop a purple tinge.

This plant is also known as Zizotes Milkweed, Hierba De Zizotes, Side-cluster Milkweed, Longhorn Milkweed, Primrose Milkweed, and Lindheimer's Milkweed. Its Spanish common name, "hierba de zizotes," means "grass of the scabby ones," and Native Americans sometimes used it to make a poultice for skin rashes.